Title (ASH)

Heparin Cofactor II-deficient Mice are Viable and Fertile

Li He and Douglas M. Tollefsen
Hematology Division, Washington University School of Medicine, St. Louis, MO 63110

1. Abstract
2. Introduction
3. Replacement vector for targeted disruption of the murine HCII gene
4. Disruption of the HCII gene in mice
5. HCII-deficient mice are viable
6. Growth of HCII-/- mice
7. Plasma HCII activity
8. Plasma antithrombin activity
9. HCII-deficient mice are fertile
10. Summary

Presented at the 42nd Annual Meeting of the American Society of Hematology
San Francisco, December 1-5, 2000

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